| Identification | Back Directory | [Name]
5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER | [CAS]
886365-06-6 | [Synonyms]
Methyl 5-broMo-4-Methylpicolinate
methyl 4-methyl-5-bromopyridinecarboxylate
Methyl 5-broMo-4-Methylpyridine-2-carboxylate
5-BroMo-4-Methyl-Pyridine-2-Carboxylicycid Methylester
5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
2-Pyridinecarboxylic acid, 5-bromo-4-methyl-, methyl ester
5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER ISO 9001：2015 REACH | [Molecular Formula]
C8H8BrNO2 | [MDL Number]
MFCD07375102 | [MOL File]
886365-06-6.mol | [Molecular Weight]
230.06 |
| Chemical Properties | Back Directory | [Boiling point ]
319.8±37.0 °C(Predicted) | [density ]
1.503±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
0.16±0.10(Predicted) | [Appearance]
White to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
To a solution of 5-bromo-4-methylpyridine-2-carboxylic acid (650 mg, 3.0 mmol) in methanol (2 mL) was added concentrated sulfuric acid (catalytic amount). The reaction mixture was heated to reflux for 14 hours. After completion of the reaction, the mixture was cooled to 0 °C and neutralized with saturated sodium bicarbonate solution to pH 7-8. The insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography using a suitable eluent (e.g. petroleum ether/ethyl acetate gradient elution) to afford methyl 5-bromo-4-methylpyridine-2-carboxylate (340 mg, 49% yield) as a white solid. | [References]
[1] Patent: US2011/71150, 2011, A1. Location in patent: Page/Page column 34
[2] Patent: US2013/158040, 2013, A1. Location in patent: Paragraph 0135
[3] Patent: US2013/158049, 2013, A1. Location in patent: Paragraph 0169
[4] Patent: US2013/158066, 2013, A1. Location in patent: Paragraph 0135 |
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