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ChemicalBook--->CAS DataBase List--->883-84-1

883-84-1

883-84-1 Structure

883-84-1 Structure
IdentificationBack Directory
[Name]

4-DEOXYPYRIDOXINE 5-PHOSPHATE
[CAS]

883-84-1
[Synonyms]

4-Deoxypyridoxine Phosphate
4-DEOXYPYRIDOXINE 5-PHOSPHATE
(5-hydroxy-4,6-dimethyl-3-pyridyl)methyl dihydrogen phosphate
(5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate
(5-hydroxy-4,6-dimethyl-pyridin-3-yl)methyl dihydrogen phosphate
3-Pyridinemethanol, 5-hydroxy-4,6-dimethyl-, 3-(dihydrogen phosphate)
[Molecular Formula]

C8H12NO5P
[MDL Number]

MFCD00056050
[MOL File]

883-84-1.mol
[Molecular Weight]

233.16
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Water: soluble
[form ]

A crystalline solid
[color ]

White to off-white
[Water Solubility ]

Water: soluble
Hazard InformationBack Directory
[Uses]

4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a Ki of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate (Ki of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase[1][2][3].
[storage]

Store at -20°C
[References]

[1] Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51(10):1207-1216. DOI:10.1007/s11745-016-4187-0
[2] M J Connor, et al. Epidermal Pyridoxal 5'-phosphate Depletion, Inhibition of DNA Synthesis, and Inhibition of the Expression of Ornithine Decarboxylase Activity by the Vitamin B-6 Antagonist 4'-deoxypyridoxine. J Invest Dermatol. 1983 Aug;81(2):136-9. DOI:10.1111/1523-1747.ep12543346
[3] D L Martin, et al. Glutamate-dependent Active-Site Labeling of Brain Glutamate Decarboxylase. J Neurochem. 1990 Aug;55(2):524-32. DOI:10.1111/j.1471-4159.1990.tb04166.x
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