| Identification | Back Directory | [Name]
BISMUTH SUBCITRATE POTASSIUM | [CAS]
880149-29-1 | [Synonyms]
2-Hydroxy-1,2,3-propanetricarboxylic acid bismuth potassium salt (2:1:5)
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, bismuth(3+) potassium salt (2:1:5) | [Molecular Formula]
C12H10BiK5O14+2 | [MDL Number]
MFCD25977749 | [MOL File]
880149-29-1.mol | [Molecular Weight]
441.21 |
| Hazard Information | Back Directory | [Uses]
7-Ethoxy-4-methylcoumarin (Standard) is the analytical standard of 7-Ethoxy-4-methylcoumarin. This product is intended for research and analytical applications. 7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6[1][2]. | [Biological Activity]
Bismuth Subcitrate potassium is an antibiotic used to treat stomach ulcers infected with Helicobacter pylori. | [in vitro]
Bismuth Subcitrate potassium crystallizes in dilute HCl at pH 3, a unique assembly of three basic bismuth citrate dimer units ([Bi(cit)2Bi]2-) forming two-dimensional sheets and three-dimensional polymers , found that the solubility of Colloidal Bismuth Subcitrate in water was greatly affected by pH, from above 70 mg/mL at pH 7, down to 1 mg/mL at pH 3. | [target]
MIC50: 8 ug/ml ( C. pyloridis ) | [storage]
Store at -20°C | [References]
[1] Van Caekenberghe DL, et al. In vitro synergistic activity between bismuth subcitrate and various antimicrobial agents against Campylobacter pyloridis (C. pylori). Antimicrob Agents Chemother. 1987 Sep;31(9):1429-30. DOI:10.1128/AAC.31.9.1429
[2] Malfertheiner P, et al. Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial. Lancet. 2011 Mar 12;377(9769):905-13. DOI:10.1016/S0140-6736(11)60020-2
[3] Hussar DA. New drugs: retapamulin, bismuth subcitrate potassium, and rotigotine. J Am Pharm Assoc (2003). 2007 Jul-Aug;47(4):539-43. DOI:10.1331/JAPhA.2007.07511 |
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