| Identification | Back Directory | [Name]
PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE | [CAS]
877997-98-3 | [Synonyms]
Acotiamide Impurity 35
Alcotimide intermediate 2
PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE
Phenyl 2-hydroxy-4,5-dimethyoxybenzoate
Phenyl -2-hydroxy -4,5-dimethyl benzoate
2-Hydroxy-4,5-dimethoxybenzoic acid phenyl ester
Benzoic acid,2-hydroxy-4,5-dimethoxy-,phenyl ester
Ethyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate
Benzoic acid,2-hydroxy-4,5-dimethoxy-,phenyl ester (for Acotiamide)
4, 5-dimethoxybenzoic acid, phenyl ester, 2-hydroxy-4, 5-dimethoxybenzoic acid
Phenyl 2-hydroxy-4,5-dimethoxybenzoate Benzoic acid,2-hydroxy-4,5-dimethoxy-,phenyl ester (for Acotiamide) | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C15H14O5 | [MDL Number]
MFCD08063359 | [MOL File]
877997-98-3.mol | [Molecular Weight]
274.27 |
| Chemical Properties | Back Directory | [Boiling point ]
431.2±45.0 °C(Predicted) | [density ]
1.250±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
8.83±0.23(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
(1) Toluene (1.5 g), triphenyl phosphite (2.35 g), 2-hydroxy-4,5-dimethoxybenzoic acid (1.5 g) and concentrated sulfuric acid (40.3 μL) were mixed in a reaction flask under argon protection. The reaction mixture was refluxed under stirring conditions for 2.5 hours. After completion of the reaction, it was cooled to room temperature, methanol (5 g) was added and stirring was continued for 30 min. Subsequently, water (2.5 g) was added to the mixture and stirred for another 30 minutes. The precipitated crystals were filtered and dried under reduced pressure to afford phenyl 2-hydroxy-4,5-dimethoxybenzoate (2.0 g) in 96% yield. | [References]
[1] Patent: WO2006/22252, 2006, A1. Location in patent: Page/Page column 11
[2] Patent: US2013/253222, 2013, A1. Location in patent: Paragraph 0039
[3] Patent: CN105439977, 2016, A. Location in patent: Paragraph 0016 |
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