| Identification | Back Directory | [Name]
2-cyclohexylsulfonyl-N,N-dimethyl-4-(4-methylphenyl)sulfonyl-1,3-thiazol-5-amine | [CAS]
875158-73-9 | [Synonyms]
2-cyclohexylsulfonyl-N,N-dimethyl-4-(4-methylphenyl)sulfonyl-1,3-thiazol-5-amine | [Molecular Formula]
C18H24N2O4S3 | [MOL File]
875158-73-9.mol | [Molecular Weight]
428.59 |
| Chemical Properties | Back Directory | [Boiling point ]
625.6±65.0 °C(Predicted) | [density ]
1.343±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Chloroform: soluble | [form ]
A crystalline solid | [pka]
-3.47±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
M04 is an agonist of STING. It induces the expression of the IFN reporter gene in HEK293T cells expressing wild-type human STING, but does not induce this expression in HEK293T cells expressing the R71H-G230A-R293Q (HAQ) STING variant or in mouse RAW 264.7 cells, indicating that its activity is dependent on allelic and species variations. M04 induces the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs). At a concentration of 50 μM, M04 stimulates dendritic cells isolated from PBMCs to express the MHC class II cell surface receptor HLA-DR and co-stimulatory molecules CD40, CD80, and CD86, and also enhances their ability to activate T cells in an ex vivo assay. M04 can be used in research on inflammatory immune diseases[1]. | [Biological Activity]
M04 is an agonist of stimulator of interferon genes (STING).1 It induces IFN reporter gene expression in HEK293T cells expressing wild-type human STING but not in HEK293T cells expressing the R71H-G230A-R293Q (HAQ) human STING variant nor in mouse RAW 264.7 cells, indicating allelic- and species-dependent activities, at 75 μM. M04 induces the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs). It increases the percentage of isolated human monocyte-derived dendritic cells expressing the MHC class II cell surface receptor HLA-DR and the co-stimulatory molecules CD40, CD80, and CD86, as well as increases T cell cross-priming of the same cells in an ex vivo assay, when used at a concentration of 50 μM. | [storage]
-20°C | [References]
1.Abraham, J., Botto, S., Mizuno, N., et al.Characterization of a novel compound that stimulates STING-mediated innate immune activity in an allele-specific mannerFront. Immunol.111430(2020)
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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www.biorbyt.com |
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PHARMEKS Ltd.
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+7 (495) 702-9648 |
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www.pharmeks.com |
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