| Identification | Back Directory | [Name]
BENZENEMETHANOL, 2-BROMO-6-NITRO- | [CAS]
861106-91-4 | [Synonyms]
(2-Bromo-6-nitrophenyl)
2-Bromo-6-nitrobenzyl alcohol
(2-BROMO-6-NITROPHENYL)METHANOL
(2-BroMo-6-notrophenyl)Methanol
2-bromo-6-nitro benzenemethanol
BENZENEMETHANOL, 2-BROMO-6-NITRO-
2-Bromo-6-nitrobenzyl alcohol 97% | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C7H6BrNO3 | [MDL Number]
MFCD11036298 | [MOL File]
861106-91-4.mol | [Molecular Weight]
232.03 |
| Chemical Properties | Back Directory | [Boiling point ]
332.6±27.0 °C(Predicted) | [density ]
1.767 | [refractive index ]
1.633 | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
crystalline powder | [pka]
13.36±0.10(Predicted) | [color ]
Gold to faint cream |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-bromo-6-nitrobenzyl ester (536 mg, 1.96 mmol) as raw material for 2-bromo-6-nitrobenzyl alcohol: 2-bromo-6-nitrobenzyl ester was dissolved in 10% aqueous acetic acid (20 mL) and 1.5 mL of acetic acid was added. The reaction mixture was heated to reflux overnight. After the reaction was completed, it was cooled to room temperature and the reaction mixture was extracted with ethyl acetate. The organic phases were combined, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 2-bromo-6-nitrobenzenemethanol (389 mg, 86% yield) as a yellow solid.1H NMR (CDCl3, 300 MHz) δ: 4.93 (d, J = 7.43 Hz), 7.354 (t, J = 8.10 Hz), 7.84 (dd, J = 1.23 Hz, 8.17 Hz), 7.89 (dd, J = 1.22 Hz, 8.03 Hz). | [References]
[1] Patent: WO2005/67933, 2005, A1. Location in patent: Page/Page column 62-63
[2] Patent: US2011/288086, 2011, A1. Location in patent: Page/Page column 29-30
[3] Patent: EP2592083, 2013, A1. Location in patent: Paragraph 0264
[4] Patent: WO2014/125408, 2014, A2. Location in patent: Page/Page column 21
[5] Patent: CN108191871, 2018, A. Location in patent: Paragraph 0245; 0252-0254 |
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