| Identification | Back Directory | [Name]
Benzenepropanoic acid, 4-[[2',6'-dimethyl-4'-[(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)oxy][1,1'-biphenyl]-3-yl]methoxy]-2-fluoro- | [CAS]
858097-86-6 | [Synonyms]
TP-051
Benzenepropanoic acid, 4-[[2',6'-dimethyl-4'-[(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)oxy][1,1'-biphenyl]-3-yl]methoxy]-2-fluoro- | [Molecular Formula]
C29H31FO6S | [MOL File]
858097-86-6.mol | [Molecular Weight]
526.62 |
| Hazard Information | Back Directory | [Uses]
TP-051 is a potent FFAR1 agonist with an Ki value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes[1]. | [References]
[1] Mikami S, et al. Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes. J Med Chem. 2012 Apr 26;55(8):3756-76. DOI:10.1021/jm2016123 |
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