| Identification | Back Directory | [Name]
N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide | [CAS]
857290-04-1 | [Synonyms]
PF 915275
PF 915275;PF915275
N-(6-aminopyridin-2-yl)-4-(4-cyanophenyl)benzenesulfonamide
N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide
[1,1'-Biphenyl]-4-sulfonamide, N-(6-amino-2-pyridinyl)-4'-cyano- | [Molecular Formula]
C18H14N4O2S | [MDL Number]
MFCD12828758 | [MOL File]
857290-04-1.mol | [Molecular Weight]
350.39 |
| Chemical Properties | Back Directory | [Boiling point ]
610.9±65.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
7.97±0.29(Predicted) | [color ]
White to pink |
| Hazard Information | Back Directory | [Biological Activity]
PF-915275 is an orally activepotent and selective 11beta-hydroxysteroid dehydrogenase type 1 (11?-HSD1HSD11B1) inhibitor (human 11?-HSD1 Ki <1 nM; cellular IC50 = 5 nM using human 11?-HSD1-transfected HEK293) with reduced potency toward non-human species (human/monkey/dog hepatocytes EC50 = 20/100/120 nM; mouse 11?-HSD1 Ki = 750 nMr at hepatoma EC50 = 14 μM). PF-915275 (0.1-3-mg/kg via nasogastric intubations) inhibits prednisone-to-prednisolone conversion in cynomolgus monkeys (by 87% with 3 mg/kg) in vivo and reduces plasma insulin increase following prednisone & resumed feeding (4 hrs post PF-915275) among overnight fasted monkeys. | [storage]
Store at RT |
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