| Identification | Back Directory | [Name]
8-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione | [CAS]
851941-94-1 | [Synonyms]
CM026
CM-026
CM 026
8-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
1H-Purine-2,6-dione, 8-[[4-(2-furanylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)- | [Molecular Formula]
C22H30N6O4 | [MOL File]
851941-94-1.mol | [Molecular Weight]
442.51 |
| Hazard Information | Back Directory | [Uses]
CM026 is a selective aldehyde dehydrogenase 1A1 inhibitor with submicromolar inhibitory activity against aldehyde dehydrogenase 1A1. Its inhibitory mechanism is related to binding to the aldehyde binding pocket and utilizing a unique glycine residue. It can be used as a chemical tool to study the role of this enzyme in disease. | [References]
[1] Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity DOI:10.1016/j.bioorg.2020.103971
[2] Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors |
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