| Identification | Back Directory | [Name]
Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]- | [CAS]
85141-94-2 | [Synonyms]
Bromo-PEG4
Br-PEG4-OH
85141-94-2
Bromo-PEG4-alcohol
Br-PEG4-OH, Bromo-PEG4-alcohol
2-[2-[2-(2-BroMoethoxy)ethoxy]ethoxy]-ethanol
Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]- | [Molecular Formula]
C8H17BrO4 | [MDL Number]
MFCD18205852 | [MOL File]
85141-94-2.mol | [Molecular Weight]
257.12 |
| Chemical Properties | Back Directory | [Boiling point ]
321.7±27.0 °C(Predicted) | [density ]
1.350±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C8H17BrO4/c9-1-3-11-5-7-13-8-6-12-4-2-10/h10H,1-8H2 | [InChIKey]
CERQCRALBKUCTF-UHFFFAOYSA-N | [SMILES]
C(O)COCCOCCOCCBr |
| Hazard Information | Back Directory | [Description]
Bromo-PEG4-alcohol is a PEG linker containing a bromide group and a terminal hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. | [Uses]
Br-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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