| Identification | Back Directory | [Name]
BOC-2-AMINO-4-THIAZOLE-CARBOXYLIC ACID | [CAS]
83673-98-7 | [Synonyms]
N-BOC protected
2-Boc-AminothiazoL
3-thiazole-4-carboxylic acid
2-BOC-AMINOTHIAZOLE-4-CARBOXYLIC ACID
BOC-2-AMINO-4-THIAZOLE-CARBOXYLIC ACID
BOC-2-AMINO-4-THIAZOLE-CARBIXYLIC ACID
N-Boc-2-aMino thiazole-4-carboxylic acid
2-(tert-butoxycarbonyl)thiazole-4-carboxylic acid
2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID
3-tert-butoxycarbonylamino-thiazole-4-carboxylic acid
2-AMINO-1,3-THIAZOLE-4-CARBOXYLIC ACID N-BOC PROTECTED
2-tert-Butoxycarbonylaminothiazole-4-carboxylicacid95%
2-Amino-1,3-thiazole-4-carboxylic acid, 2-BOC protected
2-Amino-1,3-thiazole-4-carboxylic acid, N-BOC protected 95%
2-Amino-1,3-thiazole-4-carboxylic acid, 2-BOC protected 95%
2-{[(tert-butoxy)carbonyl]aMino}-1,3-thiazole-4-carboxylic acid
4-Thiazolecarboxylicacid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-
2-[(tert-Butoxycarbonyl)amino]-1,3-thiazole-4-carboxylic acid, 2-[(tert-Butoxycarbonyl)amino]-4-carboxy-1,3-thiazole | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C9H12N2O4S | [MDL Number]
MFCD02181057 | [MOL File]
83673-98-7.mol | [Molecular Weight]
244.27 |
| Chemical Properties | Back Directory | [Melting point ]
250-252 | [density ]
1.406±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [form ]
solid | [pka]
5.53±0.70(Predicted) | [color ]
Pale yellow | [InChI]
InChI=1S/C9H12N2O4S/c1-9(2,3)15-8(14)11-7-10-5(4-16-7)6(12)13/h4H,1-3H3,(H,12,13)(H,10,11,14) | [InChIKey]
PIWSRJPUYPNQJE-UHFFFAOYSA-N | [SMILES]
S1C=C(C(O)=O)N=C1NC(OC(C)(C)C)=O |
| Hazard Information | Back Directory | [Synthesis]
GENERAL METHOD: An aqueous KOH solution (10% w/v) was added to a THF solution containing ethyl 2-((tert-butoxycarbonyl)amino)thiazole-4-carboxylate. The reaction mixture was stirred at room temperature until the complete disappearance of the ingredients was confirmed by thin layer chromatography (TLC). Subsequently, the pH was adjusted to 4 by adding 1 M HCl and the reaction solution was extracted with ethyl acetate (EtOAc). The organic layer was dried with anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under reduced pressure to afford the target product 2-Boc-aminothiazole-4-carboxylic acid. | [References]
[1] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 776 - 788
[2] Patent: US2006/41146, 2006, A1. Location in patent: Page/Page column 15
[3] Journal of the American Chemical Society, 2000, vol. 122, # 27, p. 6382 - 6394
[4] Chinese Chemical Letters, 2015, vol. 26, # 10, p. 1315 - 1318
[5] Patent: US2002/173490, 2002, A1 |
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