| Identification | Back Directory | [Name]
2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID | [CAS]
83265-53-6 | [Synonyms]
PO-081211
BUTTPARK 24\07-92
4-Amino-3-carboxybenzotrifluoride
2-Amino-5-trifuloromethylbenzoic acid
2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID
Benzoic acid, 2-amino-5-(trifluoromethyl)-
2-Amino-5-(trifluoromethyl)benzoicacid,95%
2-Amino-5-(trifluoromethyl)benzoic acid 98%
4-Amino-3-carboxybenzotrifluoride, 2-Carboxy-4-(trifluoromethyl)aniline | [EINECS(EC#)]
207-163-9 | [Molecular Formula]
C8H6F3NO2 | [MDL Number]
MFCD01569537 | [MOL File]
83265-53-6.mol | [Molecular Weight]
205.134 |
| Chemical Properties | Back Directory | [Melting point ]
141-146℃ | [Boiling point ]
301.6±42.0 °C(Predicted) | [density ]
1.489±0.06 g/cm3(Predicted) | [Fp ]
>110°(230°F) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
Solid | [pka]
4.51±0.10(Predicted) | [Appearance]
White to light yellow Solid |
| Hazard Information | Back Directory | [Uses]
2-amino-5-(trifluoromethyl)benzoic Acid is a benzoic acid derivative whose molecular structure contains substituents amino and trifluoromethyl at positions 2 and 5. The substance can be used to prepare small molecule inhibitors or anticancer drugs, and is widely used in fields such as chemical or pharmaceutical manufacturing. | [Synthesis]
Step 2 Synthesis of 2-amino-5-(trifluoromethyl)benzoic acid: 2-nitro-5-(trifluoromethyl)benzoic acid (1.2 g, 4.78 mmol) was suspended in ethanol (10 mL) and 10% Pd/C catalyst (120 mg) was added. The hydrogenation reaction was carried out at room temperature and atmospheric pressure for 1 hour. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated to afford 2-amino-5-(trifluoromethyl)benzoic acid (900 mg, 85.2% yield) as a pale white solid. The resulting product could be used in subsequent reactions without further purification. | [References]
[1] Patent: WO2016/23826, 2016, A1. Location in patent: Page/Page column 52; 53 |
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