| Identification | Back Directory | [Name]
H-LYS-GLN-ALA-GLY-ASP-VAL-OH | [CAS]
80755-87-9 | [Synonyms]
KQAGDV
LYS-GLN-ALA-GLY-ASP-VAL
Fibrinogen γ-chain fragmen
Fibrinogen γ-chain fragment
H-LYS-GLN-ALA-GLY-ASP-VAL-OH
L-Valine, L-lysyl-L-glutaminyl-L-alanylglycyl-L-α-aspartyl- | [Molecular Formula]
C25H44N8O10 | [MDL Number]
MFCD00133515 | [MOL File]
80755-87-9.mol | [Molecular Weight]
616.66 |
| Hazard Information | Back Directory | [Uses]
Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is the six most carboxyl-terminal amino acids in the fibrinogen γ-chain sequence. Lys-Gln-Ala-Gly-Asp-Val is a cell adhesion peptide which is mediated through the α2bβ3 integrin. Lys-Gln-Ala-Gly-Asp-Val is a potent adhesion ligand for smooth muscle cells (SMCs)[1][2]. | [Definition]
ChEBI: Lys-Gln-Ala-Gly-Asp-Val is an oligopeptide. | [Biochem/physiol Actions]
Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is a cell adhesion peptide used to study adhesion of platelets to neutrophils via the integrin glycoproteins gpIIb/IIIa. | [References]
[1] Dong CL, et al. The cytocompatability of polyhydroxyalkanoates coated with a fusion protein of PHA repressor protein (PhaR) and Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) polypeptide. Biomaterials. 2012 Mar;33(9):2593-9. DOI:10.1016/j.biomaterials.2011.12.020
[2] Mann BK, et al. Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells. Biomaterials. 2001 Mar;22(5):439-44. DOI:10.1016/s0142-9612(00)00196-4 |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|