726174-52-3

805250-17-3

Methyl 2-(6-hydroxybenzofuran-3-yl)acetate (2 g, 9.71 mmol) was used as starting material and dissolved in methanol. A catalytic amount of palladium carbon (0.2 g) was added and three hydrogen substitutions were performed to exclude air. Subsequently, the reaction was stirred at room temperature for 24 h under hydrogen atmosphere. Upon completion of the reaction, the filtration was carried out using diatomaceous earth as a filter aid and the filter cake was washed with an appropriate amount of solvent. The filtrates were combined and the solvent was removed by distillation under reduced pressure to afford the off-white powdery solid product methyl 2,3-dihydro-6-hydroxy-3-coumarone acetate (1.93 g, 95% yield).