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ChemicalBook--->CAS DataBase List--->804519-64-0

804519-64-0

804519-64-0 Structure

804519-64-0 Structure
IdentificationBack Directory
[Name]

Yonkenafil Hydrochloride
[CAS]

804519-64-0
[Synonyms]

Yonkenafil HCl
Yonkenafil Hydrochloride
[Molecular Formula]

C24H34ClN5O4S
[MOL File]

804519-64-0.mol
[Molecular Weight]

524.08
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Description]

Yonkenafil HCl is a PDE5 inhibitor potentially for the treatment of erectile dysfunction.
[Uses]

Yonkenafil (Tunodafil) hydrochloride, a novel phosphodiesterase 5 (PDE5) inhibitor, is effective in reducing cerebral infarction, neurological deficits, edema, and neuronal damage in the infarcted area. Yonkenafil (Tunodafil) hydrochloride may improve cognitive function by modulating neurogenesis and has a potential therapeutic effect on Alzheimer's disease[1].
[in vivo]

Yonkenafil (Tunodafil) hydrochloride (4-32 mg/kg, i.v. daily for 7?days) improves behavioral outcomes after stroke and reduces cerebral infarct volume, inhibits neuronal apoptosis, and significantly enhances synaptic function in ischemic brain by modulating the expression of BDNF/TrkB and NGF/TrkA[1].

Animal Model:Male Sprague-Dawley (SD) Rat[1]
Dosage:4, 8, 16 and 32??mg/kg
Administration:i.v. daily for 7?days
Result:Induced a dose-dependent decrease in infarct volume, with an ED50 of 12.27 mg/kg.
Increased hsp70 expression, decreased apaf-1 expression, and inhibited caspase-3 and caspase-9 cleavage.
Significantly prevented neuronal damage and increases the number of surviving neurons after stroke.
Prevented decrease in synaptophysin levels and increase in PSD-95 and nNOS levels.
[IC 50]

PDE5
[References]

[1] Xuemei Chen, et al. Yonkenafil: a novel phosphodiesterase type 5 inhibitor induces neuronal network potentiation by a cGMP-dependent Nogo-R axis in acute experimental stroke. Exp Neurol. 2014 Nov;261:267-77. DOI:10.1016/j.expneurol.2014.07.007
804519-64-0 suppliers list
Company Name: TargetMol Chemicals Inc.
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