| Identification | Back Directory | [Name]
Pyrimidine, 5-bromo-2-(trifluoromethyl)- | [CAS]
799557-86-1 | [Synonyms]
EOS-62113
5-Bromo-2-(trifluoromethyl)pyrimidine
5-Bromo-2-(trifluoromethyl)-1,3-diazine
Pyrimidine, 5-bromo-2-(trifluoromethyl)-
5-Bromo-2-(trifluoromethyl)pyrimidine 96%
5-Bromo-2-(trifluoromethyl)pyrimidine,95%
5-Bromo-2-(trifluoromethyl)pyrimidine, tech
5-bromo-2-(trifluoromethyl)pyrimidine ISO 9001：2015 REACH | [EINECS(EC#)]
690-872-4 | [Molecular Formula]
C5H2BrF3N2 | [MDL Number]
MFCD09754046 | [MOL File]
799557-86-1.mol | [Molecular Weight]
226.98 |
| Chemical Properties | Back Directory | [Melting point ]
41-42° | [Boiling point ]
139.8±40.0 °C(Predicted) | [density ]
1.807±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [form ]
Crystalline | [pka]
-3.28±0.22(Predicted) | [color ]
White | [InChI]
InChI=1S/C5H2BrF3N2/c6-3-1-10-4(11-2-3)5(7,8)9/h1-2H | [InChIKey]
GIFDWXWNFKZVEI-UHFFFAOYSA-N | [SMILES]
C1(C(F)(F)F)=NC=C(Br)C=N1 |
| Hazard Information | Back Directory | [Uses]
5-bromo-2-(trifluoromethyl)pyrimidine was used in the preparation of pyrimidinone compounds as Lp-PLA2 inhibitors.
| [Synthesis]
General procedure for the synthesis of 5-bromo-2-trifluoromethylpyrimidine using 2-trifluoromethylpyrimidine as starting material: 24 g of 2-trifluoromethylpyrimidine was dissolved in 200 ml of acetic acid and 50 g of bromine was added slowly and dropwise. The reaction mixture was heated to reflux and kept reacting overnight. After completion of the reaction, it was cooled to room temperature and extracted by adding appropriate amount of water and ethyl acetate. The organic and aqueous phases were separated and the organic phase was collected. The organic phase was dried with anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 29 g of 5-bromo-2-trifluoromethylpyrimidine. | [References]
[1] Patent: CN108129456, 2018, A. Location in patent: Paragraph 0020; 0021-0022
[2] Patent: CN108218792, 2018, A. Location in patent: Paragraph 0020; 0021; 0022 |
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