午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

ChemicalBook--->CAS DataBase List--->796854-35-8

796854-35-8

796854-35-8 Structure

796854-35-8 Structure
IdentificationBack Directory
[Name]

WAY-204688
[CAS]

796854-35-8
[Synonyms]

SIM-688
WAY-204688
1-Piperidinepropanenitrile, α-[(S)-(2-methoxyphenyl)-1-naphthalenylmethyl]-α-methyl-β-oxo-4-[3-(trifluoromethyl)phenyl]-, (αS)-
[Molecular Formula]

C34H31F3N2O2
[MDL Number]

MFCD30532597
[MOL File]

796854-35-8.mol
[Molecular Weight]

556.63
Chemical PropertiesBack Directory
[Boiling point ]

708.7±60.0 °C(Predicted)
[density ]

1.231±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

-1.66±0.40(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

WAY-204688 is an estrogen receptor (ER-α) selective, orally active inhibitor of NF-κB transcriptional activity with an IC50 of 122?±?30 nM for NF-κB-luciferase (NF-κB-luc) in HAECT-1 cells.
[in vivo]

WAY-204688 (5 mg/kg per day, po daily for 5 weeks) is evaluated in vivo for the ability to inhibit four proinflammatory genes (MHC, invariant chain (MHI), VCAM-1, RANTES, and TNF-α). The effect of WAY-204688 on induction of the gene products and on uterine wet weight is compared to that of 17α-ethinyl 17β-estradiol (EE at 10 μg/kg per day) in the same paradigm. Further characterization of WAY-204688 is carried out in several preclinical models of inflammatory disease. In the Lewis rat adjuvant-induced arthritis model (AIA), WAY-204688 is active at a dose of 0.3 mg/kg per day, po[1].

[IC 50]

NF-κB-luc: 122 nM (IC50, in HAECT-1 cell); NF-κB
[References]

[1] Caggiano TJ, et al. Estrogen receptor dependent inhibitors of NF-kappaB transcriptional activation-1 synthesis and biological evaluation of substituted 2-cyanopropanoic acid derivatives: pathway selective inhibitors of NF-kappaB, a potential treatment for rheumatoid arthritis. J Med Chem. 2007 Nov 1;50(22):5245-8. DOI:10.1021/jm701013k
Spectrum DetailBack Directory
[Spectrum Detail]

WAY-204688(796854-35-8)1HNMR
796854-35-8 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: ShangHai Biochempartner Co.,Ltd  
Tel: 177-54423994 17754423994
Website: www.biochempartner.com
Company Name: Shanghai SuperLan Chemcial Technique Centre  
Tel: 021-2022843681 15618226720
Website: www.yuhua99.com/ShowSupplierProductsList19886/0_EN.htm
Company Name: Chuzhou KeMail Chemical Technology Co., Ltd  
Tel: 0550-5196001 15000891977
Website: www.yuhua99.com/ShowSupplierProductsList19947/0_EN.htm
Company Name: Shenzhen Polymeri Biochemical Technology Co., Ltd.  
Tel: +86-400-002-6226 +86-13028896684;
Website: https://www.rrkchem.com
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Website: http://www.chemegen.com
Company Name: cjbscvictory  
Tel: 13348960310
Website: https://www.weikeqi-biotech.com/
Company Name: Bide Pharmatech Ltd.  
Tel: 400-1647117 13681763483
Website: https://www.bidepharm.com/
Company Name: Chengdu PEIP Pharmaceutical Technology Co., LTD.  
Tel: 028-61715638 18011352545
Website: www.yuhua99.com/ShowSupplierProductsList554034/0_EN.htm
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Website: https://www.targetmol.cn/
Company Name: Suzhou Haiben Pharmaceutical Co., Ltd  
Tel: 19353112242
Website:
Company Name: Shanghai?Medlife?Pharm-Tech?Co.,?Ltd  
Tel: 021-59167510 18117107507
Website: www.med-life.cn/
Company Name: Nanjing Bic Biotechnology Co., Ltd  
Tel: 025-58906079 17352406906
Website: www.bicbiotech.com/
Company Name: RD International Technology Co., Limited  
Tel: 18024082417
Website: www.ruidiresearch.com
Company Name: Sangon Biotech (Shanghai) Co.,Ltd.  
Tel: 400-821-026
Website: www.sangon.com
Company Name: Adooq Bioscience LLC  
Tel: 400-025-6535
Website: http://www.adooq.cn
Tags:796854-35-8 Related Product Information
915759-45-4 162760-96-5 1207064-61-6 1062159-35-6 1123231-07-1 220460-92-4 440122-66-7

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.