| Identification | Back Directory | [Name]
BREVETOXIN B | [CAS]
79580-28-2 | [Synonyms]
gb2
t4-7
btx-b
GBTX-2
PBTX-2
gb2toxin
t4-7toxin
toxint-34
BREVETOXIN 2
BREVETOXIN B
brevetoxint34
BREVETOXIN PBTX-2
Gb 2 (gymnodinium)
Brevetoxinpbtx-2-20c
BREVETOXIN PBTX-2, PTYCHODISCUS BREVIS
1H-Pyrano(2'',3'':5',6')pyrano(2',3':5,6)pyrano(3,2-B)pyrano(2'''''',3'''''':5''''',6''''')pyrano(2''''',3''''':5'''',6'''')pyrano(2'''',3'''':6''',7''')oxepino(2''',3''':6'',7'')oxepino(2'',3'':5',6')pyrano(2',3':5,6)pyrano(2,3-G)oxocin-3-propanal, 2,3,4A,5,5A,6A,9,9A,10A,11,11A,12A,13,14,14A,15A,16,16A,18,20A,21A,22,22A,23A,24,25,25A,26A,27,27A,28A,29,29A,30A-tetratriacontahydro-1-hydroxy-9A,13,20,21A,25A,26A,30A-heptamethyl-alpha-methylene-18-oxo-, (1S-(1alpha,3alpha,4aalpha,5aalpha,6aalpha,9aalpha,10aalpha, 11aalpha,12aalpha,13beta,14aalpha,15aalpha,16aalpha,20abeta, 21abeta,22abeta,23abet | [Molecular Formula]
C50H70O14 | [MDL Number]
MFCD00214092 | [MOL File]
79580-28-2.mol | [Molecular Weight]
895.08 |
| Chemical Properties | Back Directory | [Melting point ]
270(Disassembly) | [density ]
1.188±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Ethyl Acetate: soluble | [form ]
A film | [pka]
13.72±0.70(Predicted) | [color ]
tan to white | [Optical Rotation]
+154.022 (CHCl3) | [Water Solubility ]
ethyl acetate: soluble
methanol: soluble
water: soluble |
| Hazard Information | Back Directory | [Description]
Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning. | [Uses]
Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. | [Definition]
ChEBI: Brevetoxin B is a ciguatoxin. |
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Energy Chemical
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cjbscvictory
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Merck KGaA
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Cellosaurus STR
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