Identification | Back Directory | [Name]
2-Pyridinecarboxamide, N-(2,4-dichlorophenyl)- | [CAS]
794544-99-3 | [Synonyms]
TAS4 TAS-4 TAS 4 2-Pyridinecarboxamide, N-(2,4-dichlorophenyl)- | [Molecular Formula]
C12H8Cl2N2O | [MOL File]
794544-99-3.mol | [Molecular Weight]
267.11 |
Hazard Information | Back Directory | [Description]
TAS-4 is a metabotropic glutamate receptor 4-positive allosteric modulator. | [Uses]
TAS-4 is a potent and selective mGluR4 positive allosteric modulator with significant anti-Parkinson's disease activity. TAS-4 is able to show efficacy when used alone or in combination with l-DOPA. TAS-4 is able to reverse haloperidol-induced spasticity when administered alone. TAS-4 enhances the contralateral rotation behavior induced by l-DOPA in a dose-dependent manner. TAS-4 combined with low-dose l-DOPA shows anti-Parkinson's effects similar to full-dose l-DOPA without exacerbating abnormal motor side effects[1]. | [References]
[1] Therapeutic potential of metabotropic glutamate receptor 4-positive allosteric modulator TAS-4 in rodent models of movement disorders DOI:10.1016/j.jns.2014.07.008 |
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