| Identification | Back Directory | [Name]
6-METHOXY-3-METHYL-1H-INDAZOLE | [CAS]
7746-29-4 | [Synonyms]
6-METHOXY-3-METHYL-1H-INDAZOLE
3-METHYL-6-METHOXY 1H-INDAZOLE | [Molecular Formula]
C9H10N2O | [MDL Number]
MFCD07780793 | [MOL File]
7746-29-4.mol | [Molecular Weight]
162.19 |
| Chemical Properties | Back Directory | [Melting point ]
168-169 °C | [Boiling point ]
323.0±22.0 °C(Predicted) | [density ]
1.198±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
14.68±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
6-Methoxy-3-methyl-1H-indazole is a pharmaceutical intermediate compound that is used in the preparation of EGFR inhibitors. | [Synthesis]
General procedure for the synthesis of 6-methoxy-3-methyl-1H-indazole from 2-fluoro-4-methoxyacetophenone: 1-(2-fluoro-4-methoxyphenyl)ethan-1-one (2 g, 11.9 mmol) was dissolved in a mixture of 5 mL of hydrazine hydrate (85%) and N-methylpyrrolidone (NMP, 15 mL). The reaction mixture was stirred at 120°C for 24 hours. After completion of the reaction, the product was purified by column chromatography to afford 6-methoxy-3-methyl-1H-indazole (1.5 g, 78% yield). | [References]
[1] Patent: WO2016/8590, 2016, A1. Location in patent: Page/Page column 50
[2] Patent: EP3205650, 2017, A1. Location in patent: Paragraph 0106; 0365; 0366
[3] Patent: US6956036, 2005, B1
[4] Patent: US6552062, 2003, B1
[5] Patent: WO2009/144554, 2009, A1. Location in patent: Page/Page column 49-50 |
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| Company Name: |
SynAsst Chemical.
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021-60343070 |
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www.yuhua99.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
Cool Pharm, Ltd
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021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
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