98-60-2

837-52-5

774549-97-2

To a stirred solution of 7-chloro-4-(1-piperazinyl)quinoline (0.25 g, 1 mmol) in dichloromethane (8-10 mL) at 0 °C was added triethylamine (0.12 mL, 1.26 mmol). Subsequently, 4-chlorobenzenesulfonyl chloride (1 mmol) was added dropwise or in batches, and the reaction mixture was continued to be stirred at 0 °C for 15 min, then brought to room temperature and stirred until the reaction was complete (monitored by TLC). Upon completion of the reaction, the reaction mixture was diluted with dichloromethane (20 mL) and water (20 mL) and transferred to a partition funnel for separation. The organic layer was washed with water (3 x 20 mL) and dried over anhydrous sodium sulfate. Recrystallization by mixed solvent recrystallization of dichloromethane and hexane afforded pure 7-chloro-4-(4-((4-chlorophenyl)sulfonyl)-1-piperazinyl)quinoline in 85-95% yield.