| Identification | Back Directory | [Name]
BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2 | [CAS]
77453-01-1 | [Synonyms]
sk&f100398
M.W. 1136.41 C53H77N13O11S2
[d(CH2)5,Tyr(Et)2,Val4]arginine vasopressin
(D(CH2)(5/1),TYR(ET)2,VAL4,ARG8)-VASOPRESSIN
(B-MERCAPTO-B,B-CYCLOPENTAMETHYLENE-*PRO PIONYL1,O-E
vasopressin 1-(1-MCHA)-2-(O-ethyl-L-tyrosine)-4-L-valine
[1-MERCAPTOCYCLOHEXYL]ACETYL-TYR[O-ETHYL]-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2
[β-mercapto-β,β-cyclopentamethylenepropionyl1, o-et-tyr2, val4, arg8]-vasopressin
b-Mercapto-b,b-cyclopentaMethylene-propionyl-Tyr(Et)-Phe-Val-Asn-Cys-Pro-Arg-Gly-NH2
[BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENEPROPIONYL1,O-ET-TYR2,VAL4,ARG8]-VASOPRESSIN
BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2
1-(1-MERCAPTOCYCLOHEXANEACETIC ACID)-2-(O-ETHYL-L-TYROSINE)-4-L- VALINE-8-L-ARGININEVASOPRESSIN
N-[[1-Mercapto(1)cyclohexyl]acetyl]-O-ethyl-L-Tyr-L-Phe-L-Val-L-Asn-L-Cys(1)-L-Pro-L-Arg-Gly-NH2
N-[[1-Mercapto(1)-cyclohexyl]acetyl]-O-ethyl-L-Tyr-L-Phe-L-Val-L-Asn-L-Cys(1)-L-Pro-L-Arg-Gly-NH2
Glycinamide, O-ethyl-N-[(1-mercaptocyclohexyl)acetyl]-L-tyrosyl-L-phenylalanyl-L-valyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-arginyl-, cyclic (1→5)-disulfide (9CI) | [Molecular Formula]
C53H77N13O11S2 | [MDL Number]
MFCD00076752 | [MOL File]
77453-01-1.mol | [Molecular Weight]
1136.39 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [form ]
Solid | [color ]
White to off-white | [Sequence]
{(1-Mercaptocyclohexyl)acetyl}-{Tyr(O-Ethyl)}-Phe-Val-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: 1-Cys6) |
| Hazard Information | Back Directory | [Uses]
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP[1]. | [in vivo]
SKF 100398 is a specific antagonist of the hydrosmotic effect of exogenous and endogenous AVP[1].
SKF 100398 (8 μg/kg; i.v.) abolishes the antidiuretic effect of AVP[1].
| Animal Model: | Male Sprague-Dawley rats (250-300 g)[1] | | Dosage: | 8 μg/kg | | Administration: | Intravenous injection | | Result: | Completely blocked the antidiuretic effect of exogenous AVP (4 ng/kg body wt i.v.). |
| [References]
[1] S Ishikawa, et al. Further in vivo evidence for antagonist-to-antidiuretic action of arginine vasopressin. Am J Physiol. 1983 Nov;245(5 Pt 1):R713-9. DOI:10.1152/ajpregu.1983.245.5.R713 |
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