| Identification | Back Directory | [Name]
1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-2-oxo-N-2-propynyl-, (3aS,4S,6aR)- | [CAS]
773888-45-2 | [Synonyms]
N-Propargylbiotinamide
N-(Prop-2-ynyl)biotinamide
1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-2-oxo-N-2-propynyl-, (3aS,4S,6aR)-
1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-2-oxo-N-2-propyn-1-yl-, (3aS,4S,6aR)- | [Molecular Formula]
C13H19N3O2S | [MDL Number]
MFCD28385487 | [MOL File]
773888-45-2.mol | [Molecular Weight]
281.37 |
| Chemical Properties | Back Directory | [Melting point ]
169-170 °C | [Boiling point ]
614.8±50.0 °C(Predicted) | [density ]
1.185±0.06 g/cm3(Predicted) | [solubility ]
good in DMSO and DMF, | [form ]
Solid | [pka]
13.90±0.40(Predicted) | [color ]
White to off-white | [Water Solubility ]
low in water |
| Hazard Information | Back Directory | [Description]
Biotin alkyne is a biotinylated compound that enables simple biotinylation of antibodies, proteins and any other azide-containing biomolecules. The alkyne group of this reagent can react with azide moiety in Cu(I)-catalyzed Click Chemistry reaction to form a stable triazole linkage. | [Uses]
Biotin alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014. DOI:10.1016/j.chembiol.2020.07.020 |
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