Identification | Back Directory | [Name]
8-HYDROXYOCTANOIC ACID | [CAS]
764-89-6 | [Synonyms]
8-HYDROXYOCTANSURE 8-HYDROXYOCTANOIC ACID 8-HYDROXYCAPRYLIC ACID Octanoic acid, 8-hydroxy- 8-Hydroxyoctanoic acid,90% 8-Hydroxyoctanoic acid 98% (T) | [Molecular Formula]
C8H16O3 | [MDL Number]
MFCD00792446 | [MOL File]
764-89-6.mol | [Molecular Weight]
160.21 |
Chemical Properties | Back Directory | [Appearance]
light yellow powder | [Melting point ]
59-63 °C
| [Boiling point ]
130°C/1mm | [density ]
1.0227 (rough estimate) | [refractive index ]
1.4370 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
crystalline powder | [pka]
4.77±0.10(Predicted) | [color ]
White | [BRN ]
1237092 | [LogP]
0.900 (est) |
Hazard Information | Back Directory | [Chemical Properties]
light yellow powder | [Definition]
ChEBI: An omega-hydroxy fatty acid that is caprylic acid in which one of the hydrogens of the terminal methyl group is replaced by a hydroxy group. | [Uses]
8-Hydroxyoctanoic Acid is an intermediate in the synthesis of mono-carboxy-isooctyl-phthalate (M525590). 8-Hydroxyoctanoic Acid is also used as a reagent in the synthesis of histone deacetylases (HDAC) inhibitors with an N-formyl hydroxylamine head group which are promising targets for cancer chemotherapy. | [General Description]
8-Hydroxyoctanoic acid is one of the constituents of ‘‘Royal jelly′′ acid found in herbhoneys and genuine honeys. |
Questions And Answer | Back Directory | [Synthesis]
GENERAL PROCEDURE: All catalytic activity testing experiments were carried out in Schlenk tubes (50 mL) equipped with a condenser. 8-Hydroxycaprylic acid (HCA) was prepared by HDO oxidation reaction in alkaline aqueous medium using H2O2 as oxidant. The typical reaction procedure was as follows: first, the aliphatic diol (0.5 mmol) was weighed and dispersed with catalyst (25 mg) in deionized water (3.5 mL) in a Schlenk tube. Subsequently, 30% H2O2 (0.75 mL) and 0.5 M NaOH (0.75 mL) were added to the above mixture. The Schlenk tubes were placed in an oil bath preheated to 353 K and reacted for different time intervals under continuous magnetic stirring (500 rpm). After completion of the reaction, a portion of the reaction solution was taken and diluted 20-fold with 10 mM aqueous H2SO4 and the catalyst was removed by passing it through a 0.20 μm filter (Milex-LG). The resulting filtrate was analyzed by high performance liquid chromatography (HPLC, WATERS 600) on an Aminex HPX-87H column (Bio-Rad Laboratories, Inc.) with a refractive index detector. An aqueous solution of 10 mM H2SO4 was used as the eluent at a flow rate of 0.5 mL/min, and the column temperature was maintained at 323 K. The conversion and yield were determined by the calibration curve method for commercial products. references: [1] Catalysis Today, 2016, vol. 265, p. 231 - 239 |
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