Identification | Back Directory | [Name]
1H-PYRAZOLO[3,4-C]PYRIDIN-3-AMINE | [CAS]
76006-17-2 | [Synonyms]
4-c]pyridin-3-aMine 3-Amino-6-aza-1H-indazole 1H-PYRAZOLO[3,4-C]PYRIDIN-3-AMINE 3-Amino-1H-pyrazolo[3,4-c]pyridine 1H-Pyrazolo[3,4-c]pyridin-3-ylamine 3-Amino-1H-pyrazolo[3,4-c]pyridine 95+% 1H-Pyrazolo[3,4-c]pyridin-3-amine, 3-Amino-6-azaindole | [Molecular Formula]
C6H6N4 | [MDL Number]
MFCD11656373 | [MOL File]
76006-17-2.mol | [Molecular Weight]
134.14 |
Chemical Properties | Back Directory | [Melting point ]
213-214 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
433.5±25.0 °C(Predicted) | [density ]
1.480±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [form ]
solid | [pka]
11.83±0.40(Predicted) | [Appearance]
White to yellow Solid |
Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 1H-pyrazolo[3,4-c]pyridin-3-amine using 3-fluoro-4-cyanopyridine as starting material: 3-fluoro-4-cyanopyridine (0.50 g, 4.10 mmol) was dissolved in ethanol (8 mL), followed by addition of hydrazine hydrate (0.31 g, 6.1 mmol). The reaction mixture was stirred at 70 °C for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated and dried under vacuum to afford the target product 1H-pyrazolo[3,4-c]pyridin-3-amine (0.66 g, 100% yield). The product was characterized by LC-MS (Method 2B): retention time (Rt) = 0.51 min, mass spectrum (ESI positive ion mode): m/z = 135 [M + H]+. | [References]
[1] Patent: WO2015/67549, 2015, A1. Location in patent: Page/Page column 66 [2] Patent: US2015/126449, 2015, A1. Location in patent: Paragraph 0386 - 0388 |
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