| Identification | Back Directory | [Name]
Imanixil | [CAS]
75689-93-9 | [Synonyms]
Imanixil
HOE-402(free base)
5-Pyrimidinecarboxamide, 4-amino-2-(4,4-dimethyl-2-oxo-1-imidazolidinyl)-N-[3-(trifluoromethyl)phenyl]- | [Molecular Formula]
C17H17F3N6O2 | [MOL File]
75689-93-9.mol | [Molecular Weight]
394.35 |
| Chemical Properties | Back Directory | [density ]
1.428±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 300 mg/mL (760.75 mM) | [form ]
Solid | [pka]
10.89±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Imanixil (HOE-402 free base) is an inducer of the LDL receptor (LDLR). Imanixil (HOE-402 free base) is also a potent cholesterol-lowering compound, which inhibits very low density-lipoprotein (VLDL) production, and consequently attenuates atherosclerosis development[1]. | [storage]
Store at -20°C | [References]
[1] Draijer R, et al. HOE 402 lowers serum cholesterol levels by reducing VLDL-lipid production, and not by induction of the LDL receptor, and reduces atherosclerosis in wild-type and LDL receptor-deficient mice. Biochem Pharmacol. 2002 May 1;63(9):1755-61. DOI:10.1016/s0006-2952(02)00898-5 |
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