| Identification | Back Directory | [Name]
6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE | [CAS]
748758-45-4 | [Synonyms]
YM 298198 HYDROCHLORIDE
Thiazolo[3,2-a]benzimidazole-2-carboxamide,6-amino-N-cyclohexyl-N,3-dimethyl-
6-amino-N-cyclohexyl-N,3-dimethylbenzo[4,5]imidazo[2,1-b]thiazole-2-carboxamide
6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE | [Molecular Formula]
C18H22N4OS | [MDL Number]
MFCD08703122 | [MOL File]
748758-45-4.mol | [Molecular Weight]
342.46 |
| Hazard Information | Back Directory | [Uses]
YM 298198 Hydrochloride is a noncompetitive, high affinity, and selective antagonist of metabotropic glutamate receptor type 1 (mGluR-1). | [Definition]
ChEBI: 7-amino-N-cyclohexyl-N,1-dimethyl-2-thiazolo[3,2-a]benzimidazolecarboxamide is a member of benzimidazoles. | [Biological Activity]
Non-competitive antagonist with high affinity and selectivity for mGlu 1 receptors (K i = 19 nM); inactive at other mGlu receptor subtypes (mGlu 2-7 ), ionotropic receptors and glutamate transporters (IC 50 > 10 μ M). Inhibits glutamate-induced IP production more potently than CPCCOEt (IC 50 values are 16 nM and 6.3 μ M respectively), and is orally active in vivo , demonstrating an antinociceptive effect in hyperalgesic mice. | [storage]
+4°C (desiccate) |
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