| Identification | Back Directory | [Name]
Phenol, 4-(dimethylphenylsilyl)- | [CAS]
74027-99-9 | [Synonyms]
Estrogen receptor-IN-1
Phenol, 4-(dimethylphenylsilyl)- | [Molecular Formula]
C14H16OSi | [MOL File]
74027-99-9.mol | [Molecular Weight]
228.36 |
| Chemical Properties | Back Directory | [Boiling point ]
105-107 °C(Press: 0.003 Torr) | [density ]
1.05±0.1 g/cm3(Predicted) | [form ]
Oil | [pka]
9.72±0.26(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Estrogen receptor-IN-1 (compound 16) is a potent estrogen receptor (ER) inhibitor with IC50s of 13, 5μM for ERα and Erβ, respectively[1]. | [IC 50]
ERα: 13 μM (IC50); ERβ: 5 μM (IC50) | [References]
[1] Saito H, et al. Phosphine boranes as less hydrophobic building blocks than alkanes and silanes: Structure-property relationship and estrogen-receptor-modulating potency of 4-phosphinophenol derivatives. Bioorg Med Chem. 2020 Feb 15;28(4):115310. DOI:10.1016/j.bmc.2020.115310 |
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