| Identification | Back Directory | [Name]
4-AMinothiophene-2-carbonitrile | [CAS]
73781-74-5 | [Synonyms]
4-AMinothiophene-2-carbonitrile
4-amino-2-Thiophenecarbonitrile
2-Thiophenecarbonitrile, 4-amino- | [Molecular Formula]
C5H4N2S | [MOL File]
73781-74-5.mol | [Molecular Weight]
124.164 |
| Chemical Properties | Back Directory | [Boiling point ]
352.6±22.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
2.45±0.10(Predicted) | [Appearance]
Light brown to reddish brown Solid |
| Hazard Information | Back Directory | [Synthesis]
Step 3 Synthesis of 4-aminothiophene-2-carbonitrile (3): 4-nitrothiophene-2-carbonitrile (2) (100 mg, 0.65 mmol) was dissolved in ethyl acetate (4 mL) and dioxane (0.2 mL) and 5% Pd/C catalyst (77 mg) was added. After 16 h of reaction under hydrogen atmosphere, 10% Pd/C Degussa wet catalyst (30 mg) was added and stirring was continued for 24 h under hydrogen at 1 atmosphere. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under vacuum. The product was purified by column chromatography using 20-30% ethyl acetate/hexane as eluent to give 4-aminothiophene-2-carbonitrile (3).LRMS (ESI) Calculated value: 124.2, Measured value: 125.1 (MH)+. | [References]
[1] Patent: WO2008/104077, 2008, A1. Location in patent: Page/Page column 46; 47 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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