| Identification | Back Directory | [Name]
Benzoic acid, 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-, methyl ester | [CAS]
731006-86-3 | [Synonyms]
ML 397
VU0155094
VU0155094(ML-397)
VU0155094 (Synonyms: ML397)
Methyl 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]benzoate
Benzoic acid, 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-, methyl ester | [Molecular Formula]
C24H24N2O4S | [MDL Number]
MFCD04625924 | [MOL File]
731006-86-3.mol | [Molecular Weight]
436.52 |
| Chemical Properties | Back Directory | [Boiling point ]
667.0±55.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.56±0.70(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Description]
ML397, also known as VU0155094, is a positive allosteric modulator. ML397 showed differential activity at the various group III mGlus. Additionally, both compounds show probe dependence when assessed in the presence of distinct orthosteric agonists. | [Uses]
VU0155094 is a positive allosteric modulator with differential activity at the various group III mGluRs[1]. | [References]
[1] Jalan-Sakrikar N, et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem Neurosci. 2014 Dec 17;5(12):1221-37. DOI:10.1021/cn500153z |
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