| Identification | Back Directory | [Name]
CONGLOBATIN | [CAS]
72263-05-9 | [Synonyms]
FW-04-806
CONGLOBATIN
Conglobatin, >=99%
(3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-Hexamethyl-8,16-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione
1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (3E,5R,7S,8S,11E,13R,15S,16S)- | [Molecular Formula]
C28H38N2O6 | [MDL Number]
MFCD01730317 | [MOL File]
72263-05-9.mol | [Molecular Weight]
498.61 |
| Chemical Properties | Back Directory | [density ]
1.060±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
-20°C | [solubility ]
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | [form ]
White to off-white solid. | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Isolated from Streptomyces conglobatus, conglobatin has a unusual, dimeric, macrolide dilactone structure with pendant oxazole groups. Conglobatin exhibits an IC50 of 0.63 μg/ml in a NFAT-dependant transcription assay. No toxicity was observed at doses up to 1000 mg/kg when administered to mice either orally or interperitoneally. | [in vivo]
Conglobatin (50-200 mg/kg; i.g. q3d for 24 d) inhibits the tumor growth of SKBR3 and MCF-7 human breast cancer xenograft models in a dose-dependent manner[2].
Conglobatin (4-8 mg/kg; i.p. daily for 21 days) inhibits tumor growth in EC109 and KYSE510 tumor xenograft models with low toxicity[3] | Animal Model: | BALB/c (nu/nu) athymic mice with SKBR3 and MCF-7 tumor xenograft[2] | | Dosage: | 50, 100, 200 mg/kg | | Administration: | Oral gavage every 3 days for 24 days | | Result: | Showed inhibition of tumor growth at a rate of 39.1%, 52.7%, and 67.5% in the SKBR3 cell line groups and 27.3%, 39.8%, 54.3% in the MCF-7 cell line groups at the three increasing doses, respectively.
Was well tolerated.
|
| [IC 50]
HSP90 | [storage]
Store at -20°C |
|
| Company Name: |
Lynnchem
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86-(0)29-85992781 17792393971 |
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http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
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44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
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