62123-80-2

7194-78-7

General procedure for the synthesis of 2-(3-bromophenyl)-2-oxoacetic acid from ethyl 2-(3-bromophenyl)-2-oxoacetate: to a solution of ethyl 2-(3-bromophenyl)-2-oxoacetate (1 g, 3.9 mmol) in methanol (10 mL) was added an aqueous solution of potassium hydroxide (2 mL, 50% w/v) and the reaction mixture was stirred at room temperature for 30 min. Upon completion of the reaction, the pH was adjusted to 4 with 1 N hydrochloric acid. the reaction mixture was extracted with ethyl acetate (5 mL x 4), the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give the crude product. The crude product was used directly in the next step of the reaction without further purification (0.8 g, 89% yield). Mass spectrometry (MS) data: m/z 230 ([M-H]-).