| Identification | Back Directory | [Name]
(5Z)-6A-CARBAPROSTAGLANDIN I2 | [CAS]
69609-77-4 | [Synonyms]
5-CIS CARBAPROSTACYCLIN
(5Z)-6A-CARBAPROSTAGLANDIN I2
5 cis Carbaprostacyclin,5cis Carbaprostacyclin
6,9ALPHA-METHYLENE-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID
Pentanoic acid, 5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-1-octenyl]-2(1H)-pentalenylidene]-, (5Z)- (9CI) | [Molecular Formula]
C21H34O4 | [MDL Number]
MFCD00797659 | [MOL File]
69609-77-4.mol | [Molecular Weight]
350.49 |
| Chemical Properties | Back Directory | [Boiling point ]
514.8±50.0 °C(Predicted) | [density ]
1.177±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: >10 mg/ml (from 6B-PGI2); DMSO: >5 mg/ml (from 6B-PGI2); Ethanol: >20 mg/ml (from 6B-PGI2); PBS pH 7.2: >80 μg/ml (from 6B-PGI2) | [form ]
A crystalline solid | [pka]
4.77±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
5-cis Carbaprostacyclin is a stable analog of PGI2 based on Carbaprostacyclin (HY-112322). Carbacyclin is a PGI2 receptor agonist and vasodilator that activates PPARδ. 5-cis Carbaprostacyclin induces relaxation of pulmonary vascular tone[1][2]. | [Definition]
ChEBI: Carbacyclin is a prostanoid. | [References]
[1] Kurtz M, et al. Carbaprostacyclin, a PPARdelta agonist, ameliorates excess lipid accumulation in diabetic rat placentas. Life Sci. 2010 May 22;86(21-22):781-90. DOI:10.1016/j.lfs.2010.03.008
[2] Norel X, et al. Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713. Prostaglandins Other Lipid Mediat. 2004 Oct;74(1-4):101-12. DOI:10.1016/j.prostaglandins.2004.07.003 |
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