| Identification | Back Directory | [Name]
INTRALIPID | [CAS]
68890-65-3 | [Synonyms]
INTRALIPID
Medialipid
Fat emulsion
Intralipid 20
Lipofundin S 10
soybeanoil,phospholipid-stabilized
PHOSPHOLIPID STABILIZED SOYBEAN OIL
Soybean oil, phospholipid-stabilized (09C, 10C, 11C, 14C) | [MDL Number]
MFCD00287215 |
| Hazard Information | Back Directory | [Uses]
Intralipid has been used:
- for testing its optical properties to be used as scattering medium for tissue phantom generation
- as a component of agarose gel phantom to reduce scatter coefficients and background absorption
- in infusion into mice in hyperinsulinemic-euglycemic clamps studies to evaluate its effect on nonesterified free fatty acids (NEFA) circulation
| [Biochem/physiol Actions]
Intralipid is a lipid emulsion comprising soybean oil. It favors proinflammatory cytokines production and is recommended for the treatment of immune-mediated pregnancy and implantation failure. In parenteral nutrition, intralipid is the source of fats. It elicits protection in heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. Intralipid is an effective alternative for intravenous immunoglobulin and improves bioavailability of platinum based anti-cancer drugs. | [in vivo]
Intralipid (2 g/kg) does not affect phagocytosis and may promote macrophage polarization to the M1 phenotype, as observed in breast cancer tumor sections from Balb/c mice[1].
Intralipid pretreatment promotes the accumulation of paclitaxel in tumour tissue and induces higher levels of apoptosis in tumour cells. Increased distribution of paclitaxel in mouse RES organs and enhanced inhibition of tumour growth[1].
Intralipid (5 mL/kg) is more effective than cyclosporin-A in protecting the heart from I/R injury in SD rats, reducing the size of myocardial infarction by approximately 40%[2].
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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