| Identification | Back Directory | [Name]
BX 430 | [CAS]
688309-70-8 | [Synonyms]
BX 430
N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-(3-pyridinyl)urea
Urea, N-[2,6-dibromo-4-(1-methylethyl)phenyl]-N'-3-pyridinyl- | [Molecular Formula]
C15H15Br2N3O | [MDL Number]
MFCD02678819 | [MOL File]
688309-70-8.mol | [Molecular Weight]
413.11 |
| Chemical Properties | Back Directory | [Melting point ]
164-168°C | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White |
| Hazard Information | Back Directory | [Uses]
BX 430 is a selective P2X4 allosteric antagonist in human and zebrafish. | [Biological Activity]
BX430 is a selective noncompetitive allosteric antagonist of human P2X4 receptor channels. P2X4 receptors are highly expressed in the CNSand have been studied as a therapeutic target for neuropathic pain and inflammationand treatment of traumatic brain injurycerebral ischemiaand spinal cord injury. BX430 is highly selective for human P2X4with minimal activity towards other P2X subtypesincluding P2X1–P2X3P2X5and P2X7. BX430 is also an antagonist of zebrafish P2X4 but has no effect on r at and mouse P2X4 receptors. BX430 has an IC50 value of 540 nM. | [storage]
Store at +4°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|