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ChemicalBook--->CAS DataBase List--->685119-25-9

685119-25-9

685119-25-9 Structure

685119-25-9 Structure
IdentificationBack Directory
[Name]

Benzamide, N-[2-bromo-4-(phenylsulfonyl)-3-thienyl]-2-chloro-
[CAS]

685119-25-9
[Synonyms]

BNTA
Benzamide, N-[2-bromo-4-(phenylsulfonyl)-3-thienyl]-2-chloro-
[Molecular Formula]

C17H11BrClNO3S2
[MOL File]

685119-25-9.mol
[Molecular Weight]

456.76
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

BNTA, a potent extracellular matrix (ECM) modulator, facilitates cartilage structural molecule synthesis on chondrocytes by activating superoxide dismutase 3 (SOD3). BNTA shows a promising potential for osteoarthritis alleviation by modulating cartilage generation[1].
[in vivo]

BNTA (0.015-1.5 mg/kg; intra-articular injection; twice a week for 4 and 8 weeks) could attenuate OA progression developed after anterior cruciate ligament transection (ACLT) in rats[1].

Animal Model:Male SD rats weighing 80?g are induced by ACLT[1]
Dosage:0.015, 0.15, 1.5 mg/kg
Administration:Intra-articular injection; twice a week for 4 and 8 weeks
Result:Attenuated post-traumatic osteoarthritis development after intra-articular injection for 4 and 8 weeks and was well tolerated.
[References]

[1] Shi Y, et, al. A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development. Nat Commun. 2019 Apr 23; 10(1): 1914. DOI:10.1038/s41467-019-09839-x
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