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ChemicalBook--->CAS DataBase List--->684645-54-3

684645-54-3

684645-54-3 Structure

684645-54-3 Structure
IdentificationBack Directory
[Name]

EF 1502 racemic
[CAS]

684645-54-3
[Synonyms]

EF1502
EF-1502
EF 1502
S)-EF 1502
Rac-EF 1502
(R,S)-EF 1502
EF 1502 racemic
EF1502 free base
[Molecular Formula]

C22H26N2O2S2
[MOL File]

684645-54-3.mol
[Molecular Weight]

414.58
Hazard InformationBack Directory
[Description]

EF1502 is a potent and selective GABA transporter inhibitor. EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol.
[Uses]

EF-1502 is a potent and selective GABA transporter inhibitor with GAT1 and BGT1 inhibitory activity. EF-1502 produces a synergistic anti-epileptic effect when used in combination with Tiagabine (HY-B0696), a compound used to suppress epileptic seizures. The dosing combination of EF-1502 exhibited reduced anti-epileptic efficacy and dyskinesia when used with THIP (HY-10232). The mechanism of EF-1502 differs significantly from Tiagabine, suggesting a unique role in the inhibitory strategy[1].
[References]

[1] Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol DOI:10.1124/jpet.111.179671
684645-54-3 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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