| Identification | More | [Name]
2-BROMOACETAMIDE | [CAS]
683-57-8 | [Synonyms]
2-BROMOACETAMIDE
BROMOACETAMIDE
2-bromo-acetamid
Acetamide, 2-bromo-
2-Bromoacetamide98%
2-Bromoacetamide,97%
2-BROMOACETAMIDE pure | [EINECS(EC#)]
226-270-1 | [Molecular Formula]
C2H4BrNO | [MDL Number]
MFCD00008025 | [Molecular Weight]
137.96 | [MOL File]
683-57-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Very faintly beige fine crystals | [Melting point ]
87-91 °C(lit.) | [Boiling point ]
271.6±23.0 °C(Predicted) | [density ]
1.4243 (rough estimate) | [refractive index ]
1.4740 (estimate) | [storage temp. ]
Store at RT. | [solubility ]
160g/l | [form ]
Crystalline Powder | [pka]
14.79±0.40(Predicted) | [color ]
White | [BRN ]
1739073 | [InChI]
InChI=1S/C2H4BrNO/c3-1-2(4)5/h1H2,(H2,4,5) | [InChIKey]
JUIKUQOUMZUFQT-UHFFFAOYSA-N | [SMILES]
C(N)(=O)CBr | [CAS DataBase Reference]
683-57-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T,C | [Risk Statements ]
R25:Toxic if swallowed.
R34:Causes burns.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2923 8/PG 2
| [WGK Germany ]
3
| [RTECS ]
AB4587000
| [F ]
10 | [Hazard Note ]
Irritant | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29241990 |
| Hazard Information | Back Directory | [Hazard]
A poison by ingestion. Moderately toxic by
skin contact. A severe skin and eye irritant.
| [Chemical Properties]
Very faintly beige fine crystals | [Uses]
2-Bromoacetamide was used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator. | [General Description]
Kinetics of reaction of 2-bromoacetamide with a 39 base pair duplex DNA sequence was studied. | [Synthesis]
Step 1: To a dichloromethane solution containing the amine (300 mg, 0.71 mmol) and potassium carbonate (290 mg, 2.1 mmol) obtained from Step 1 of Example 51 was slowly added bromoacetyl chloride (71 μL, 0.85 mmol) at room temperature. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction mixture was washed with 0.1 N NaOH aqueous solution and subsequently dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was purified by silica gel column chromatography (eluent: dichloromethane/ethyl acetate, 9:1, v/v) to afford the target product 2-bromoacetamide 281 mg in 73% yield. | [References]
[1] Journal of the American Chemical Society, 1939, vol. 61, p. 3386
[2] Patent: US2003/216380, 2003, A1 |
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