| Identification | Back Directory | [Name]
7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE | [CAS]
6742-12-7 | [Synonyms]
formycin
NSC 102811
formycin A
FORMYCIN MONOHYDRATE
FORMYCIN A MONOHYDRATE
8-Aza-9-deazaadenosine
8-AZA-9-DEAZAADENOSINE MONOHYDRATE
3-β-D-Ribofuranosyl-1H-pyrazolo[4,3-d]pyrimidine-7-amine
3-(β-D-Ribofuranosyl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine
3-d)pyrimidine,7-amino-3-beta-d-ribofuranosyl-1h-pyrazolo(
7-Amino-3-(β-D-ribofuranosyl)-1H-pyrazolo[4,3-d]pyrimidine
7-amino-3-beta-d-ribofuranosyl-1h-pyrazolo(4,3-d)pyrimidine
1-C-(7-Amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-, (1S)-
3-d)pyrimidin-3-yl)-1,4-anhydro-1-c-(7-amino-1h-pyrazolo((s)-d-ribito
7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE
(1S)-1-C-(7-Amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol
D-Ribitol, 1-C-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-, (1S)- | [Molecular Formula]
C10H13N5O4 | [MDL Number]
MFCD07995039 | [MOL File]
6742-12-7.mol | [Molecular Weight]
267.25 |
| Chemical Properties | Back Directory | [Melting point ]
141-144 °C (decomp) | [Boiling point ]
709.5±60.0 °C(Predicted) | [density ]
1.771±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO: soluble1mg/mL | [form ]
powder | [pka]
8.37±0.50(Predicted) | [color ]
white to off-white | [BRN ]
624229 |
| Hazard Information | Back Directory | [Description]
Formycin (Formycin A) is isolated
from Nocardia interforma and from Streptomyces
lavendulae , . The antibiotic
is effective against Xanthomonas oryzae
and Pellicularia filamentosa. Its activity against
Yoshida rat sarcoma cell is enhanced by coformycin.
Formycin B inhibits Xanthomonas
oryzae and interferes with multiplication of influenza A virus in the cells of chick
chorioallantoic membrane . Oxoformycin
B shows no activity against Xanthomonas
oryzae . | [Uses]
Formycin A (NSC 102811), a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM. Formycin A shows antitumor and antiviral activities[1][2]. | [Definition]
ChEBI: Formycin A is a formycin. It has a role as an antineoplastic agent. | [IC 50]
HIV-1: 10 μM (EC50) | [References]
[1] Dapp MJ , et al. Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1.J Virol. 2014 Jan;88(1):354-63. DOI:10.1128/JVI.02444-13
[2] Zhang M, et al. Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds. Appl Environ Microbiol. 2020 Jan 7;86(2). DOI:10.1128/AEM.01971-19 |
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