| Identification | Back Directory | [Name]
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione | [CAS]
666816-98-4 | [Synonyms]
Linagliptin INT1
8-BROMO-7-(BUT-2-YNYL)
Linagliptin Impurity 36
Linagliptin Impurity 73
Iinagliptin Intermediate2
Linagliptin interMediateC
8-BROMO-3-METHYL-7-BUT-2-YNYL XANTHINE
8-bromo-7 -(2-butynyl) -3-methylxanthine
3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine
3-Methyl-7-(2-butin-1-yl)-8-broMoxanthine
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine
LINAGLIPTIN CAS 668270-12-0 INTERMEDIATES
8- bromo -7-(2- butyne)-3- methyl xanthine
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine >
Hydrazinecarbothioamide,N-(10-methoxyphenyl)-
8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3
8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dion
8-Bromo-7-(2-butynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
8-broMo-7-(but-2-ynyl)-3-Methyl-3,7-dihydropurine-2,6-dione
8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1Hpurin-2,6(3H,7H)-dione
8-broMo-7-(but-2-yn-1-yl)-3-Methyl-1H-purine-2,6(3H,7H)-dione
8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione
8-bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-indole-2,6-dione
8-bromo-3-methyl-7-(prop-1-yn-1-yl)-1H-purine-2,6(3H,7H)-dione
8-bromo-7-but-2-yn-1-yl-3-methyl-3,7-dihydro-1H-purine-2,6-d...
8-Bromo-7-(2- butynyl)-3,7-dihydro- 3-methyl-1H-pur ine-2,6-dion
1H-Purine-2,6-dione, 8-broMo-7-(2-butynyl)-3,7-dihydro-3-Methyl-
8-broMo-7-but-2-yn-1-yl-3-Methyl-3,7-dihydro-1H-purine-2,6-dione
8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione
1H-Purine-2,6-dione, 8-bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-
8-BroMo-7-(2-butyn-a-yl)-3,7-dihydro-3-Methyl-1-1H-purine-2,6-dione
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione USP/EP/BP
8-bromo-7-(but-2-ynyl)-3-methyl-3,4,5,7-tetrahydro-1H-purine-2,6-dione
8-Bromo-7-But-2-Ynyl-3-Methyl-Purine-2,6-Dione / Linagliptin Intermediate
Linagliptin intermediates，8-bromo-7-(but-2-ynyl)-3-methyl-1H- purine-2,6(3H,7H)-dione
Linagliptin intermediate 8-bromo-7-but-2-yn-1-yl-3-methyl-3,7-dihydro-1H-purine-2,6-dione
(2-(chloromethyl)-4-methylquinazoline)，8-bromo-7-(but-2-ynyl)-3-methyl-1H- purine-2,6(3H,7H)-dione
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione/3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine
3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine 8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione
(R)-tert-butyl 1-(7-(but-2-ynyl)-3-Methyl-1-((4-Methylquinazolin-2-yl)Methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-ylcarbaMate
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine]Q: What is
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine] Q: What is the CAS Number of
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine] Q: What is the storage condition of
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine] | [EINECS(EC#)]
613-975-8 | [Molecular Formula]
C10H9BrN4O2 | [MDL Number]
MFCD22126091 | [MOL File]
666816-98-4.mol | [Molecular Weight]
297 |
| Chemical Properties | Back Directory | [Melting point ]
285 °C | [density ]
1.71 | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
powder to crystal | [pka]
8.91±0.70(Predicted) | [color ]
White to Almost white | [InChI]
InChI=1S/C10H9BrN4O2/c1-3-4-5-15-6-7(12-9(15)11)14(2)10(17)13-8(6)16/h5H2,1-2H3,(H,13,16,17) | [InChIKey]
HFZOBQSHTNNKFY-UHFFFAOYSA-N | [SMILES]
N1(CC#CC)C2=C(N(C)C(=O)NC2=O)N=C1Br | [LogP]
1.25 at 20℃ | [CAS DataBase Reference]
666816-98-4 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Synthesis]
8-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione (2.450 g, 10 mmol),1-bromo-2-butyne (1.596 g, 12 mmol), Sodium carbonate (1.590 g, 15 mmol), and 20mL of acetone was added to a 100mL flask. The reaction system was heated to 40 ° C, and the reaction was stirred for 4h. After the reaction was cooled to room temperature, suction filtration was performed, and the filter cake was washed with methanol to obtain a crude product as a pale yellow solid. The crude product was reconstituted with dichloromethane and cyclohexane. Yield 2.912 g of 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione. The yield was 98%, and the purity was 99.9%. | [References]
[1] Patent: US2015/274728, 2015, A1. Location in patent: Paragraph 0056-0060
[2] Patent: , 2016, . Location in patent: Paragraph 0097;0098
[3] Patent: WO2014/97314, 2014, A1. Location in patent: Page/Page column 9
[4] Patent: CN104292228, 2016, B. Location in patent: Paragraph 0057-0058; 0089-0092
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 26, p. 6450 - 6453 |
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