| Identification | Back Directory | [Name]
ETHYL 3-AMINO-4-(METHYLAMINO)BENZOATE | [CAS]
66315-23-9 | [Synonyms]
Ethyl 3-amino-4-(methylamino)
Thyl3-amino-4-(methylamino)benzoate
ETHYL 3-AMINO-4-(METHYLAMINO)BENZOATE
3-Amino-4-(methylamino)benzoic acid ethyl ester
Benzoic acid, 3-amino-4-(methylamino)-, ethyl ester | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C10H14N2O2 | [MDL Number]
MFCD04110945 | [MOL File]
66315-23-9.mol | [Molecular Weight]
194.23 |
| Chemical Properties | Back Directory | [Melting point ]
87 °C | [Boiling point ]
357.4±32.0 °C(Predicted) | [density ]
1.173±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
5.45±0.11(Predicted) | [Appearance]
Brown to black Solid |
| Hazard Information | Back Directory | [Definition]
ChEBI: Ethyl 3-amino-4-(methylamino)benzoate is a benzoate ester. | [Synthesis]
Step 1-1-3 Synthesis of ethyl 3-amino-4-methylaminobenzoate: Ethyl 4-methylamino-3-nitrobenzoate (6.80 g, 30.3 mmol) prepared in Step 1-1-2 was dissolved in methanol (200 mL), and 5% palladium carbon catalyst (1.10 g) was added to the solution. The reaction mixture was stirred overnight at room temperature under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford ethyl 3-amino-4-methylaminobenzoate (4.85 g, 82% yield) as a light brown powder. The product was characterized by 1H-NMR (CDCl3): δ 7.92 (dd, J = 1.9, 8.5 Hz, 1H), 7.40 (d, J = 1.9 Hz, 1H), 6.58 (d, J = 8.5 Hz, 1H), 4.31 (q, J = 7.3 Hz, 2H), 3.99 (brs, 1H), 3.22 (brs, 2H), and 2.19 (s, 3H), 1.36 (t, J = 7.3 Hz, 3H). Mass spectral analysis showed m/z: 194 (M+, base peak), 149. | [References]
[1] Patent: US2013/79306, 2013, A1. Location in patent: Paragraph 0234; 0235; 0236; 0237
[2] Chem.Abstr., 1978, vol. 89, # 61044,
[3] Chem.Abstr., vol. 89, # 61044, |
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