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ChemicalBook--->CAS DataBase List--->660843-21-0

660843-21-0

660843-21-0 Structure

660843-21-0 Structure
IdentificationBack Directory
[Name]

O-[2-(Boc-aMino)ethyl]-O′-(2-MaleiMidoethyl)ethylene glycol
[CAS]

660843-21-0
[Synonyms]

O-[2-(Boc-aMino)ethyl]-O′-(2-MaleiMidoethyl)ethylene glycol
O-[2-(Boc-amino)ethyl]-O'-(2-maleimidoethyl)ethylene glycol >=96.0% (HPLC)
tert-Butyl {2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethyl}carbamate
Carbamic acid, N-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester
[Molecular Formula]

C15H24N2O6
[MDL Number]

MFCD12912379
[MOL File]

660843-21-0.mol
[Molecular Weight]

328.36
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

Soluble in DMSO, DCM
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

Mal-PEG2-NH-Boc is a PEG linker containing a maleimide group and a Boc protected amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
[Uses]

Mal-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs; Alkyl/ether
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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