| Identification | Back Directory | [Name]
N-(4-(4-(3-Methyl-1H-pyrazol-5-ylaMino)-6-(4-Methylpiperazin-1-yl)pyriMidin-2-ylthio)phenyl)propionaMide | [CAS]
639089-73-9 | [Synonyms]
N-(4-(4-(3-Methyl-1H-pyrazol-5-ylaMino)-6-(4-Methylpiperazin-1-yl)pyriMidin-2-ylthio)phenyl)propionaMide
Propanamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]- | [Molecular Formula]
C22H28N8OS | [MDL Number]
MFCD32068314 | [MOL File]
639089-73-9.mol | [Molecular Weight]
452.58 |
| Hazard Information | Back Directory | [Description]
VE-465 is a novel Aurora kinase inhibitor. The Aurora kinase family of kinases (Aurora A, B, and C) are involved in multiple mitotic events, and aberrant expression of these kinases is associated with tumorigenesis. | [Uses]
VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell apoptosis. VE-465 has anticancer effects in multiple tumor models[1][2]. | [References]
[1] Lin ZZ, et al. The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma. J Hepatol. 2009 Mar;50(3):518-27. DOI:10.1016/j.jhep.2008.10.022
[2] Evans R, et al. Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells. Leuk Lymphoma. 2008 Mar;49(3):559-69. DOI:10.1080/10428190701824544 |
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