| Identification | Back Directory | [Name]
ethyl 3-amino-3-phenylpropanoate | [CAS]
6335-76-8 | [Synonyms]
NSC 38811
-propionic acid ethyL
ethyl 3-amino-3-phenylpropanoate
Ethyl 3-amino-3-phenylpropionate
ETHYL-3-AMINO-3-PHENYLPROPANOATEhyHCL
Ethyl 3-amino-3-phenylpropionate 95+%
3-Amino-3-phenylpropanoic acid ethyl ester
beta-Aminobenzenepropanoic acid ethyl ester
Benzenepropanoic acid, β-amino-, ethyl ester
Benzenepropanoic acid, b-aMino-, ethyl ester
Ethyl 3-amino-3-phenyl-propanoate hydrochloride
3-Amino-3-phenylpropanoic acid ethyl ester hydrochloride | [Molecular Formula]
C11H15NO2 | [MDL Number]
MFCD00749016 | [MOL File]
6335-76-8.mol | [Molecular Weight]
193.24 |
| Chemical Properties | Back Directory | [Melting point ]
111-112℃ (water ethanol ) | [Boiling point ]
155 °C(Press: 13 Torr) | [density ]
1.075±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
7.75±0.10(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
To a 500 mL three-necked flask was added 50 mL of ethanol, 9.3 g of malonic acid and 18.2 g of ammonium acetate, heated to 50°C, and 10.0 g of benzaldehyde was slowly added dropwise. After the dropwise addition, the reaction was heated to reflux. After the reaction was completed, the mixture was cooled to below 10°C and 40 g of thionyl chloride was slowly added dropwise. The mixture was heated to reflux for 16 hours, followed by distillation to remove ethanol. To the residue 50 mL of dichloromethane was added and the pH was adjusted to 6-7 with 5 N NaOH solution. the organic layer was separated and the aqueous layer was extracted with dichloromethane. The organic layers were combined and concentrated to give 14.2 g of colorless oily material, which was analyzed by HPLC for 98% purity and 78% yield. | [References]
[1] Patent: CN106083624, 2016, A. Location in patent: Paragraph 0019 |
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