| Identification | Back Directory | [Name]
(+/-)-THREO-3-METHYLGLUTAMIC ACID | [CAS]
63088-04-0 | [Synonyms]
3MG
T3MG
Threo-3-Me-Glu-OH
(3S)-rel-3-Methyl-
threo-3-Methylglutamate
threo-β-methylglutamic acid
threo-3-Methyl-DL-glutamic Acid
(3S)-rel-3-Methyl-D-glutamic Acid
(+/-)-THREO-3-METHYLGLUTAMIC ACID
D-GlutaMic acid, 3-Methyl-, (3S)-rel-
(+/-)-THREO-3-METHYLGLUTAMIC ACID USP/EP/BP | [Molecular Formula]
C6H11NO4 | [MDL Number]
MFCD00673930 | [MOL File]
63088-04-0.mol | [Molecular Weight]
161.16 |
| Chemical Properties | Back Directory | [Boiling point ]
329.4±32.0 °C(Predicted) | [density ]
1.329±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
H2O: >1.5mg/dL | [form ]
powder | [pka]
2.20±0.10(Predicted) | [color ]
white to off-white | [Water Solubility ]
H2O: >1.5mg/dL |
| Hazard Information | Back Directory | [Uses]
A highly selective and potent agonist for kainate receptors. | [Biological Activity]
T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1EAAT2and EAAT4. T3MG has long been utilized as a gold standard in the study of general EA at function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compoundsthis is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselvesnor does it have activity at glutamate ion channels. | [IC 50]
EAAT2; EAAT4 | [storage]
Store at RT |
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