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ChemicalBook--->CAS DataBase List--->62774-96-3

62774-96-3

62774-96-3 Structure

62774-96-3 Structure
IdentificationBack Directory
[Name]

Tilisolol HCl
[CAS]

62774-96-3
[Synonyms]

N 696
Selecal
Tilisolol HCl
trade name Selecal
tilisolol hydrochloride
Tilisolol, trade name Selecal
4-(3-(tert-ButylaMino)-2-hydroxypropoxy)-2-Methylisoquinolin-1(2H)-one hydrochloride
1(2H)-Isoquinolinone, 4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-2-methyl-, monohydrochloride (9CI)
[MDL Number]

MFCD00896575
[MOL File]

62774-96-3.mol
Chemical PropertiesBack Directory
[Melting point ]

203-205°
[storage temp. ]

Sealed in dry,Room Temperature
Hazard InformationBack Directory
[Description]

Tilisolol hydrochloride is a long acting vasodilating beta-blocker useful in the treatment of hypertension and angina. It is also reported to have antiarrhythmic properties. Due to its relatively long half-life, tilisolol hydrochloride is suitable for once a day dosing. It is currently being investigated as an antiglaucoma agent.
[Originator]

Nisshin Flour Milling (Japan)
[Definition]

ChEBI: Tilisolol hydrochloride is a member of isoquinolines.
[Brand name]

Daim; Selecal
Safety DataBack Directory
[Toxicity]

LD50 in male, female mice and rats (mg/kg): 1393, 1290, 145, 188 orally; 1219, 1245, 176, 169 s.c.; 578, 557, 39.5, 29.2 i.p.; 74.3, 104.7, 75.8, 38.1 i.v. (Kawase)
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