| Identification | Back Directory | [Name]
3,4,6-Trichloropyridazine | [CAS]
6082-66-2 | [Synonyms]
3,4,6-TrichL
6-Trichloropyridazine
3,4,6-TRICHLOROPYRIDAZINE
3,4,6-Trichloro-1,2-diazine
Pyridazine, 3,4,6-trichloro-
3-METHYL-2-BENZOXAZOLINONE,PLANT STANDARD
3,4,6-Trichloropyridazine ISO 9001：2015 REACH | [EINECS(EC#)]
629-902-8 | [Molecular Formula]
C4HCl3N2 | [MDL Number]
MFCD00834957 | [MOL File]
6082-66-2.mol | [Molecular Weight]
183.42 |
| Chemical Properties | Back Directory | [Melting point ]
55.0 to 59.0 °C | [Boiling point ]
98°C/43mmHg(lit.) | [density ]
1.641±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
-2.72±0.10(Predicted) | [color ]
White to Light yellow to Light orange | [λmax]
305nm(EtOH)(lit.) | [InChI]
InChI=1S/C4HCl3N2/c5-2-1-3(6)8-9-4(2)7/h1H | [InChIKey]
LJDQXQOPXOLCHL-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NN=C(Cl)C=C1Cl |
| Hazard Information | Back Directory | [Uses]
3,4,6-Trichloropyridazine was used to study chloropyridazine derivatives as human rhinovirus capsid-binding inhibitors. | [Synthesis]
The general procedure for the synthesis of 3,4,6-trichloropyridazine from 3,6-dichloropyridazine is as follows: 44 g of 3,6-dichloropyridazine and 22 g of aluminum trichloride were mixed and heated to 140°C. The mixture was then heated to 140°C for 4 hours. At this temperature, 10.6 liters of chlorine gas were slowly passed over a period of 4 hours. Upon completion of the reaction, the reaction mixture was cooled and extracted with toluene. The extract was subsequently washed with 10% sodium chloride solution and finally the product was purified by distillation to collect a fraction with a boiling point of 127-129 °C. Finally 44.1 g of 3,4,6-trichloropyridazine was obtained. | [References]
[1] Patent: EP1900735, 2008, A1. Location in patent: Page/Page column 9
[2] Patent: US2010/305102, 2010, A1. Location in patent: Page/Page column 17
[3] Patent: US2012/28932, 2012, A1
[4] Patent: US2013/237527, 2013, A1. Location in patent: Paragraph 0236; 0237 |
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