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ChemicalBook--->CAS DataBase List--->60563-36-2

60563-36-2

60563-36-2 Structure

60563-36-2 Structure
IdentificationBack Directory
[Name]

DCEBIO
[CAS]

60563-36-2
[Synonyms]

DCEBIO
5,6-DICHLORO-1-ETHYL-1H-BENZO[D]IMIDAZOL-2(3H)-ONE
5,6-DICHLORO-1-ETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE
5,6-DICHLORO-1-ETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOLE-2-ONE
2H-Benzimidazol-2-one, 5,6-dichloro-1-ethyl-1,3-dihydro-
[Molecular Formula]

C9H8Cl2N2O
[MDL Number]

MFCD04040030
[MOL File]

60563-36-2.mol
[Molecular Weight]

231.08
Chemical PropertiesBack Directory
[Melting point ]

205-207 °C(Solv: ethyl acetate (141-78-6))
[density ]

1.412±0.06 g/cm3(Predicted)
[storage temp. ]

Store at RT
[solubility ]

DMSO: >10mg/mL
[form ]

solid
[pka]

10.28±0.30(Predicted)
[color ]

off-white
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl- secretion in T84 colonic cells. DCEBIO stimulates Cl- secretion via the activation of hIK1 K+ channels and the activation of an apical membrane Cl- conductance. 
[Uses]

DCEBIO is a small Ca2+sensitive K+ channel (SKCa) agonist. It also stimulate nitric oxide (NO) synthesis and vasodilation in resistance arteries.
[Definition]

ChEBI: DCEBIO is a dichlorobenzene.
[Biological Activity]

Stimulates Cl - secretion via activation of hIK1 K + channels and the activation of an apical Cl - conductance. More potent than its analog 1-EBIO (1-Ethyl-2-benzimidazolinone ).
[storage]

Store at RT
Spectrum DetailBack Directory
[Spectrum Detail]

DCEBIO(60563-36-2)1HNMR
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