| Identification | Back Directory | [Name]
Benzenepropanoic acid, 3-amino-4-[(2,3-dihydro-1H-inden-2-yl)oxy]-5-(1-methyl-1H-indazol-5-yl)- | [CAS]
590416-75-4 | [Synonyms]
AK-106
AK106-001616
Benzenepropanoic acid, 3-amino-4-[(2,3-dihydro-1H-inden-2-yl)oxy]-5-(1-methyl-1H-indazol-5-yl)- | [Molecular Formula]
C26H25N3O3 | [MOL File]
590416-75-4.mol | [Molecular Weight]
427.49 |
| Hazard Information | Back Directory | [Uses]
AK106-001616 is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) (IC50=3.8 nmol/L). AK106-001616 is able to reduce the production of prostaglandins (PG) E2 and leukotrienes (LT) B4 by stimulated cells. AK106-001616 can be used in the study of inflammatory diseases, neuropathic pain and pulmonary fibrosis[1]. | [References]
[1] Shimizu, Hirotomo, et al. AK106-001616, a potent and selective inhibitor of cytosolic phospholipase A2: in vivo efficacy for inflammation, neuropathic pain, and pulmonary fibrosis. Journal of Pharmacology and Experimental Therapeutics 369.3 (2019): 511-522. DOI:10.1124/jpet.118.255034 |
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