| Identification | Back Directory | [Name]
H-4-NITRO-PHE-OET HCL | [CAS]
58816-66-3 | [Synonyms]
-OEt.HCl
H-Phe(4-NO2)
H-4-Nitro-Phe-OEt
4-NO2-L-Phe-OEtHCl
H-PHE(4-NO2)-OET HCL
H-4-NITRO-PHE-OET HCL
(S)-β-(p-Nitrophenyl)alanine
H-4-Nitro-Phe-Oet Hydrochloride
H-4-NITRO-PHE-OET HCL USP/EP/BP
3-(4-NITRO-PHENYL)-L-ALANINE ETHYL ESTER HCL
Ethyl 4-nitro-L-phenylalanine (hydrochloride)
p-Nitrophenylalanine ethyl ester hydrochloride
ETHYL (S)-2-AMINO-3-(4-NITROPHENYL)PROPANOIATE
P-NITRO-L-PHENYLALANINE ETHYL ESTER HYDROCHLORIDE
4-NITRO-L-PHENYLALANINE ETHYL ESTER HYDROCHLORIDE
ethyl 4-nitro-3-phenyl-L-alaninate monohydrochloride
4-Nitro-L-phenylalanine ethyl ester monohydrochloride
ethyl (2S)-2-amino-3-(4-nitrophenyl)propanoate hydrochloride
(S)-ethyl 2-aMino-3-(4-nitrophenyl)propanoate (Hydrochloride)
(S)-2-Amino-3-(4-nitro-phenyl)-propionic acid ethyl ester hydrochloride | [EINECS(EC#)]
261-455-0 | [Molecular Formula]
C11H15ClN2O4 | [MDL Number]
MFCD08275409 | [MOL File]
58816-66-3.mol | [Molecular Weight]
274.7 |
| Chemical Properties | Back Directory | [Melting point ]
177-180 °C | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
3-(4-Nitro-phenyl)-L-alanine ethyl ester hydrochloride is an alanine derivative[1]. | [Synthesis]
Thionyl chloride (21 mL, 0.29 mol) was slowly added dropwise to 500 mL of anhydrous ethanol at 0 °C and under nitrogen protection for a controlled time of 5 min. After the dropwise addition, the clarified reaction solution was continued to be stirred at 0 °C for 10 min, and then brought to room temperature and stirred for 30 min. A one-time addition of 4-nitro-L-phenylalanine (50.2 g, 0.24 mol) was added to the reaction system and the mixture was heated to reflux overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure to afford ethyl (S)-2-amino-3-(4-nitrophenyl)propionate hydrochloride (60 g, 92% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, CD3OD): δ 8.21 (d, 2H), 7.54 (d, 2H), 4.39 (dd, 1H), 4.22 (q, 2H), 3.24-3.40 (m, 2H), 1.22 (t, 3H). | [storage]
Store at -20°C | [References]
[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368 |
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